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- Title
Requirement of Mis6 centromere connector for localizing a CENP-A-like protein in fission yeast.
- Authors
Takahashi, K; Chen, E S; Yanagida, M
- Abstract
Mammalian kinetochores contain the centromere-specific histone H3 variant CENP-A, whose incorporation into limited chromosomal regions may be important for centromere function and chromosome segregation during mitosis. However, regulation of CENP-A localization and its role have not been clear. Here we report that the fission yeast homolog SpCENP-A is essential for establishing centromere chromatin associated with equal chromosome segregation. SpCENP-A binding to the nonrepetitious inner centromeres depended on Mis6, an essential centromere connector protein acting during G1-S phase of the cell cycle. Mis6 is likely required for recruiting SpCENP-A to form proper connection of sister centromeres.
- Publication
Science (New York, N.Y.), 2000, Vol 288, Issue 5474, p2215
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.288.5474.2215