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- Title
Role of CD47 as a marker of self on red blood cells.
- Authors
Oldenborg, P A; Zheleznyak, A; Fang, Y F; Lagenaur, C F; Gresham, H D; Lindberg, F P
- Abstract
The immune system recognizes invaders as foreign because they express determinants that are absent on host cells or because they lack "markers of self" that are normally present. Here we show that CD47 (integrin-associated protein) functions as a marker of self on murine red blood cells. Red blood cells that lacked CD47 were rapidly cleared from the bloodstream by splenic red pulp macrophages. CD47 on normal red blood cells prevented this elimination by binding to the inhibitory receptor signal regulatory protein alpha (SIRPalpha). Thus, macrophages may use a number of nonspecific activating receptors and rely on the presence or absence of CD47 to distinguish self from foreign. CD47-SIRPalpha may represent a potential pathway for the control of hemolytic anemia.
- Publication
Science (New York, N.Y.), 2000, Vol 288, Issue 5473, p2051
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.288.5473.2051