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- Title
Timing the ancestor of the HIV-1 pandemic strains.
- Authors
Korber, B; Muldoon, M; Theiler, J; Gao, F; Gupta, R; Lapedes, A; Hahn, B H; Wolinsky, S; Bhattacharya, T
- Abstract
HIV-1 sequences were analyzed to estimate the timing of the ancestral sequence of the main group of HIV-1, the strains responsible for the AIDS pandemic. Using parallel supercomputers and assuming a constant rate of evolution, we applied maximum-likelihood phylogenetic methods to unprecedented amounts of data for this calculation. We validated our approach by correctly estimating the timing of two historically documented points. Using a comprehensive full-length envelope sequence alignment, we estimated the date of the last common ancestor of the main group of HIV-1 to be 1931 (1915-41). Analysis of a gag gene alignment, subregions of envelope including additional sequences, and a method that relaxed the assumption of a strict molecular clock also supported these results.
- Publication
Science (New York, N.Y.), 2000, Vol 288, Issue 5472, p1789
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.288.5472.1789