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- Title
A high-affinity iron permease essential for Candida albicans virulence.
- Authors
Ramanan, N; Wang, Y
- Abstract
Microbial pathogens must compete with the iron-withholding defense systems of their host to acquire this essential nutrient. Here, two high-affinity iron permease genes, CaFTR1 and CaFTR2, were isolated. CaFTR1 expression was induced under iron-limited conditions and repressed when iron supply was sufficient, whereas the expression of CaFTR2 was regulated in a reversed manner. Mutants lacking CaFTR1 but not CaFTR2 exhibited a severe growth defect in iron-deficient medium and were unable to establish systemic infection in mice. Thus, CaFTR1-mediated iron-uptake mechanism constitutes a virulence factor of Candida albicans and may be a target for the development of anti-Candida therapies.
- Publication
Science (New York, N.Y.), 2000, Vol 288, Issue 5468, p1062
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.288.5468.1062