We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22.
- Authors
Brzustowicz, L M; Hodgkinson, K A; Chow, E W; Honer, W G; Bassett, A S
- Abstract
Schizophrenia is a complex disorder, and there is substantial evidence supporting a genetic etiology. Despite this, prior attempts to localize susceptibility loci have produced predominantly suggestive findings. A genome-wide scan for schizophrenia susceptibility loci in 22 extended families with high rates of schizophrenia provided highly significant evidence of linkage to chromosome 1 (1q21-q22), with a maximum heterogeneity logarithm of the likelihood of linkage (lod) score of 6.50. This linkage result should provide sufficient power to allow the positional cloning of the underlying susceptibility gene.
- Publication
Science (New York, N.Y.), 2000, Vol 288, Issue 5466, p678
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.288.5466.678