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- Title
Insect population control using a dominant, repressible, lethal genetic system.
- Authors
Thomas, D D; Donnelly, C A; Wood, R J; Alphey, L S
- Abstract
A major modification to the sterile insect technique is described, in which transgenic insects homozygous for a dominant, repressible, female-specific lethal gene system are used. We demonstrate two methods that give the required genetic characteristics in an otherwise wild-type genetic background. The first system uses a sex-specific promoter or enhancer to drive the expression of a repressible transcription factor, which in turn controls the expression of a toxic gene product. The second system uses non-sex-specific expression of the repressible transcription factor to regulate a selectively lethal gene product. Both methods work efficiently in Drosophila melanogaster, and we expect these principles to be widely applicable to more economically important organisms.
- Publication
Science (New York, N.Y.), 2000, Vol 287, Issue 5462, p2474
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.287.5462.2474