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- Title
Positioning of the mitotic spindle by a cortical-microtubule capture mechanism.
- Authors
Lee, L; Tirnauer, J S; Li, J; Schuyler, S C; Liu, J Y; Pellman, D
- Abstract
Correct positioning of the mitotic spindle is critical for cell division and development. Spindle positioning involves a search-and-capture mechanism whereby dynamic microtubules find and then interact with specific sites on the submembrane cortex. Genetic, biochemical, and imaging experiments suggest a mechanism for cortical-microtubule capture. Bim1p, located at microtubule distal ends, bound Kar9p, a protein associated with the daughter cell cortex. Bim1p is the yeast ortholog of human EB1, a binding partner for the adenomatous polyposis coli tumor suppressor. EB1 family proteins may have a general role in linking the microtubule cytoskeleton to cortical polarity determinants.
- Publication
Science (New York, N.Y.), 2000, Vol 287, Issue 5461, p2260
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.287.5461.2260