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- Title
From sequence to chromosome: the tip of the X chromosome of D. melanogaster.
- Authors
Benos, P V; Gatt, M K; Ashburner, M; Murphy, L; Harris, D; Barrell, B; Ferraz, C; Vidal, S; Brun, C; Demailles, J; Cadieu, E; Dreano, S; Gloux, S; Lelaure, V; Mottier, S; Galibert, F; Borkova, D; Minana, B; Kafatos, F C; Louis, C; Sidén-Kiamos, I; Bolshakov, S; Papagiannakis, G; Spanos, L; Cox, S; Madueño, E; de Pablos, B; Modolell, J; Peter, A; Schöttler, P; Werner, M; Mourkioti, F; Beinert, N; Dowe, G; Schäfer, U; Jäckle, H; Bucheton, A; Callister, D M; Campbell, L A; Darlamitsou, A; Henderson, N S; McMillan, P J; Salles, C; Tait, E A; Valenti, P; Saunder, R D; Glover, D M
- Abstract
One of the rewards of having a Drosophila melanogaster whole-genome sequence will be the potential to understand the molecular bases for structural features of chromosomes that have been a long-standing puzzle. Analysis of 2.6 megabases of sequence from the tip of the X chromosome of Drosophila identifies 273 genes. Cloned DNAs from the characteristic bulbous structure at the tip of the X chromosome in the region of the broad complex display an unusual pattern of in situ hybridization. Sequence analysis revealed that this region comprises 154 kilobases of DNA flanked by 1.2-kilobases of inverted repeats, each composed of a 350-base pair satellite related element. Thus, some aspects of chromosome structure appear to be revealed directly within the DNA sequence itself.
- Publication
Science (New York, N.Y.), 2000, Vol 287, Issue 5461, p2220
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.287.5461.2220