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- Title
Candidate taste receptors in Drosophila.
- Authors
Clyne, P J; Warr, C G; Carlson, J R
- Abstract
Little is known about the molecular mechanisms of taste perception in animals, particularly the initial events of taste signaling. A large and diverse family of seven transmembrane domain proteins was identified from the Drosophila genome database with a computer algorithm that identifies proteins on the basis of structure. Eighteen of 19 genes examined were expressed in the Drosophila labellum, a gustatory organ of the proboscis. Expression was not detected in a variety of other tissues. The genes were not expressed in the labellum of a Drosophila mutant, pox-neuro70, in which taste neurons are eliminated. Tissue specificity of expression of these genes, along with their structural similarity, supports the possibility that the family encodes a large and divergent family of taste receptors.
- Publication
Science (New York, N.Y.), 2000, Vol 287, Issue 5459, p1830
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.287.5459.1830