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- Title
Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death.
- Authors
Chen, F; Hersh, B M; Conradt, B; Zhou, Z; Riemer, D; Gruenbaum, Y; Horvitz, H R
- Abstract
The Caenorhabditis elegans Bcl-2-like protein CED-9 prevents programmed cell death by antagonizing the Apaf-1-like cell-death activator CED-4. Endogenous CED-9 and CED-4 proteins localized to mitochondria in wild-type embryos, in which most cells survive. By contrast, in embryos in which cells had been induced to die, CED-4 assumed a perinuclear localization. CED-4 translocation induced by the cell-death activator EGL-1 was blocked by a gain-of-function mutation in ced-9 but was not dependent on ced-3 function, suggesting that CED-4 translocation precedes caspase activation and the execution phase of programmed cell death. Thus, a change in the subcellular localization of CED-4 may drive programmed cell death.
- Publication
Science (New York, N.Y.), 2000, Vol 287, Issue 5457, p1485
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.287.5457.1485