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- Title
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration.
- Authors
Sasaki, T; Irie-Sasaki, J; Jones, R G; Oliveira-dos-Santos, A J; Stanford, W L; Bolon, B; Wakeham, A; Itie, A; Bouchard, D; Kozieradzki, I; Joza, N; Mak, T W; Ohashi, P S; Suzuki, A; Penninger, J M
- Abstract
Phosphoinositide 3-kinases (PI3Ks) regulate fundamental cellular responses such as proliferation, apoptosis, cell motility, and adhesion. Viable gene-targeted mice lacking the p110 catalytic subunit of PI3Kgamma were generated. We show that PI3Kgamma controls thymocyte survival and activation of mature T cells but has no role in the development or function of B cells. PI3Kgamma-deficient neutrophils exhibited severe defects in migration and respiratory burst in response to heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPCR) agonists and chemotactic agents. PI3Kgamma links GPCR stimulation to the formation of phosphatidylinositol 3,4,5-triphosphate and the activation of protein kinase B, ribosomal protein S6 kinase, and extracellular signal-regulated kinases 1 and 2. Thus, PI3Kgamma regulates thymocyte development, T cell activation, neutrophil migration, and the oxidative burst.
- Publication
Science (New York, N.Y.), 2000, Vol 287, Issue 5455, p1040
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.287.5455.1040