We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Requirement of CD9 on the egg plasma membrane for fertilization.
- Authors
Miyado, K; Yamada, G; Yamada, S; Hasuwa, H; Nakamura, Y; Ryu, F; Suzuki, K; Kosai, K; Inoue, K; Ogura, A; Okabe, M; Mekada, E
- Abstract
CD9 is an integral membrane protein associated with integrins and other membrane proteins. Mice lacking CD9 were produced by homologous recombination. Both male and female CD9-/- mice were born healthy and grew normally. However, the litter size from CD9-/- females was less than 2% of that of the wild type. In vitro fertilization experiments indicated that the cause of this infertility was due to the failure of sperm-egg fusion. When sperm were injected into oocytes with assisted microfertilization techniques, however, the fertilized eggs developed to term. These results indicate that CD9 has a crucial role in sperm-egg fusion.
- Publication
Science (New York, N.Y.), 2000, Vol 287, Issue 5451, p321
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.287.5451.321