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- Title
Enhanced morphine analgesia in mice lacking beta-arrestin 2.
- Authors
Bohn, L M; Lefkowitz, R J; Gainetdinov, R R; Peppel, K; Caron, M G; Lin, F T
- Abstract
The ability of morphine to alleviate pain is mediated through a heterotrimeric guanine nucleotide binding protein (G protein)-coupled heptahelical receptor (GPCR), the mu opioid receptor (muOR). The efficiency of GPCR signaling is tightly regulated and ultimately limited by the coordinated phosphorylation of the receptors by specific GPCR kinases and the subsequent interaction of the phosphorylated receptors with beta-arrestin 1 and beta-arrestin 2. Functional deletion of the beta-arrestin 2 gene in mice resulted in remarkable potentiation and prolongation of the analgesic effect of morphine, suggesting that muOR desensitization was impaired. These results provide evidence in vivo for the physiological importance of beta-arrestin 2 in regulating the function of a specific GPCR, the muOR. Moreover, they suggest that inhibition of beta-arrestin 2 function might lead to enhanced analgesic effectiveness of morphine and provide potential new avenues for the study and treatment of pain, narcotic tolerance, and dependence.
- Publication
Science (New York, N.Y.), 1999, Vol 286, Issue 5449, p2495
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.286.5449.2495