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- Title
Implication of tubby proteins as transcription factors by structure-based functional analysis.
- Authors
Boggon, T J; Shan, W S; Santagata, S; Myers, S C; Shapiro, L
- Abstract
Tubby-like proteins (TULPs) are found in a broad range of multicellular organisms. In mammals, genetic mutation of tubby or other TULPs can result in one or more of three disease phenotypes: obesity (from which the name "tubby" is derived), retinal degeneration, and hearing loss. These disease phenotypes indicate a vital role for tubby proteins; however, no biochemical function has yet been ascribed to any member of this protein family. A structure-directed approach was employed to investigate the biological function of these proteins. The crystal structure of the core domain from mouse tubby was determined at a resolution of 1.9 angstroms. From primarily structural clues, experiments were devised, the results of which suggest that TULPs are a unique family of bipartite transcription factors.
- Publication
Science (New York, N.Y.), 1999, Vol 286, Issue 5447, p2119
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.286.5447.2119