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- Title
An essential role for BLNK in human B cell development.
- Authors
Minegishi, Y; Rohrer, J; Coustan-Smith, E; Lederman, H M; Pappu, R; Campana, D; Chan, A C; Conley, M E
- Abstract
The signal transduction events that control the progenitor B cell (pro-B cell) to precursor B cell (pre-B cell) transition have not been well delineated. In evaluating patients with absent B cells, a male with a homozygous splice defect in the cytoplasmic adapter protein BLNK (B cell linker protein) was identified. Although this patient had normal numbers of pro-B cells, he had no pre-B cells or mature B cells, indicating that BLNK plays a critical role in orchestrating the pro-B cell to pre-B cell transition. The immune system and overall growth and development were otherwise normal in this patient, suggesting that BLNK function is highly specific.
- Publication
Science (New York, N.Y.), 1999, Vol 286, Issue 5446, p1954
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.286.5446.1954