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- Title
Predicting the evolution of human influenza A.
- Authors
Bush, R M; Bender, C A; Subbarao, K; Cox, N J; Fitch, W M
- Abstract
Eighteen codons in the HA1 domain of the hemagglutinin genes of human influenza A subtype H3 appear to be under positive selection to change the amino acid they encode. Retrospective tests show that viral lineages undergoing the greatest number of mutations in the positively selected codons were the progenitors of future H3 lineages in 9 of 11 recent influenza seasons. Codons under positive selection were associated with antibody combining site A or B or the sialic acid receptor binding site. However, not all codons in these sites had predictive value. Monitoring new H3 isolates for additional changes in positively selected codons might help identify the most fit extant viral strains that arise during antigenic drift.
- Publication
Science (New York, N.Y.), 1999, Vol 286, Issue 5446, p1921
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.286.5446.1921