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- Title
Activation of PPARgamma coactivator-1 through transcription factor docking.
- Authors
Puigserver, P; Adelmant, G; Wu, Z; Fan, M; Xu, J; O'Malley, B; Spiegelman, B M
- Abstract
Transcriptional coactivators have been viewed as constitutively active components, using transcription factors mainly to localize their functions. Here, it is shown that PPARgamma coactivator-1 (PGC-1) promotes transcription through the assembly of a complex that includes the histone acetyltransferases steroid receptor coactivator-1 (SRC-1) and CREB binding protein (CBP)/p300. PGC-1 has a low inherent transcriptional activity when it is not bound to a transcription factor. The docking of PGC-1 to peroxisome proliferator-activated receptor gamma (PPARgamma) stimulates an apparent conformational change in PGC-1 that permits binding of SRC-1 and CBP/p300, resulting in a large increase in transcriptional activity. Thus, transcription factor docking switches on the activity of a coactivator protein.
- Publication
Science (New York, N.Y.), 1999, Vol 286, Issue 5443, p1368
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.286.5443.1368