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- Title
Evolutionarily conserved pathways of energetic connectivity in protein families.
- Authors
Lockless, S W; Ranganathan, R
- Abstract
For mapping energetic interactions in proteins, a technique was developed that uses evolutionary data for a protein family to measure statistical interactions between amino acid positions. For the PDZ domain family, this analysis predicted a set of energetically coupled positions for a binding site residue that includes unexpected long-range interactions. Mutational studies confirm these predictions, demonstrating that the statistical energy function is a good indicator of thermodynamic coupling in proteins. Sets of interacting residues form connected pathways through the protein fold that may be the basis for efficient energy conduction within proteins.
- Publication
Science (New York, N.Y.), 1999, Vol 286, Issue 5438, p295
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.286.5438.295