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- Title
Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila.
- Authors
Levashina, E A; Langley, E; Green, C; Gubb, D; Ashburner, M; Hoffmann, J A; Reichhart, J M
- Abstract
The antifungal defense of Drosophila is controlled by the spaetzle/Toll/cactus gene cassette. Here, a loss-of-function mutation in the gene encoding a blood serine protease inhibitor, Spn43Ac, was shown to lead to constitutive expression of the antifungal peptide drosomycin, and this effect was mediated by the spaetzle and Toll gene products. Spaetzle was cleaved by proteolytic enzymes to its active ligand form shortly after immune challenge, and cleaved Spaetzle was constitutively present in Spn43Ac-deficient flies. Hence, Spn43Ac negatively regulates the Toll signaling pathway, and Toll does not function as a pattern recognition receptor in the Drosophila host defense.
- Publication
Science (New York, N.Y.), 1999, Vol 285, Issue 5435, p1917
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.285.5435.1917