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- Title
Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50.
- Authors
Kleiman, F E; Manley, J L
- Abstract
Polyadenylation of messenger RNA precursors requires a complex protein machinery that is closely integrated with the even more complex transcriptional apparatus. Here a polyadenylation factor, CstF-50 (cleavage stimulation factor), is shown to interact in vitro and in intact cells with a nuclear protein of previously unknown function, BRCA1-associated RING domain protein (BARD1). The BARD1-CstF-50 interaction inhibits polyadenylation in vitro. BARD1, like CstF-50, also interacts with RNA polymerase II. These results indicate that BARD1-mediated inhibition of polyadenylation may prevent inappropriate RNA processing during transcription, perhaps at sites of DNA repair, and they reveal an unanticipated integration of diverse nuclear events.
- Publication
Science (New York, N.Y.), 1999, Vol 285, Issue 5433, p1576
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.285.5433.1576