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- Title
Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans.
- Authors
Hull, C M; Johnson, A D
- Abstract
Candida albicans, the most prevalent fungal pathogen in humans, is thought to lack a sexual cycle. A set of C. albicans genes has been identified that corresponds to the master sexual cycle regulators a1, alpha1, and alpha2 of the Saccharomyces cerevisiae mating-type (MAT) locus. The C. albicans genes are arranged in a way that suggests that these genes are part of a mating type-like locus that is similar to the mating-type loci of other fungi. In addition to the transcriptional regulators a1, alpha1, and alpha2, the C. albicans mating type-like locus contains several genes not seen in other fungal MAT loci, including those encoding proteins similar to poly(A) polymerases, oxysterol binding proteins, and phosphatidylinositol kinases.
- Publication
Science (New York, N.Y.), 1999, Vol 285, Issue 5431, p1271
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.285.5431.1271