We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Detecting protein function and protein-protein interactions from genome sequences.
- Authors
Marcotte, E M; Pellegrini, M; Ng, H L; Rice, D W; Yeates, T O; Eisenberg, D
- Abstract
A computational method is proposed for inferring protein interactions from genome sequences on the basis of the observation that some pairs of interacting proteins have homologs in another organism fused into a single protein chain. Searching sequences from many genomes revealed 6809 such putative protein-protein interactions in Escherichia coli and 45,502 in yeast. Many members of these pairs were confirmed as functionally related; computational filtering further enriches for interactions. Some proteins have links to several other proteins; these coupled links appear to represent functional interactions such as complexes or pathways. Experimentally confirmed interacting pairs are documented in a Database of Interacting Proteins.
- Publication
Science (New York, N.Y.), 1999, Vol 285, Issue 5428, p751
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.285.5428.751