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- Title
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.
- Authors
Brightbill, H D; Libraty, D H; Krutzik, S R; Yang, R B; Belisle, J T; Bleharski, J R; Maitland, M; Norgard, M V; Plevy, S E; Smale, S T; Brennan, P J; Bloom, B R; Godowski, P J; Modlin, R L
- Abstract
The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for many pathogens, the molecules that induce IL-12 production by macrophages and the mechanisms by which they do so remain undefined. Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs). Several lipoproteins stimulated TLR-dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway. Activation of TLRs by microbial lipoproteins may initiate innate defense mechanisms against infectious pathogens.
- Publication
Science (New York, N.Y.), 1999, Vol 285, Issue 5428, p732
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.285.5428.732