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- Title
Light-dependent sequestration of TIMELESS by CRYPTOCHROME.
- Authors
Ceriani, M F; Darlington, T K; Staknis, D; Más, P; Petti, A A; Weitz, C J; Kay, S A
- Abstract
Most organisms have circadian clocks consisting of negative feedback loops of gene regulation that facilitate adaptation to cycles of light and darkness. In this study, CRYPTOCHROME (CRY), a protein involved in circadian photoperception in Drosophila, is shown to block the function of PERIOD/TIMELESS (PER/TIM) heterodimeric complexes in a light-dependent fashion. TIM degradation does not occur under these conditions; thus, TIM degradation is uncoupled from abrogation of its function by light. CRY and TIM are part of the same complex and directly interact in yeast in a light-dependent fashion. PER/TIM and CRY influence the subcellular distribution of these protein complexes, which reside primarily in the nucleus after the perception of a light signal. Thus, CRY acts as a circadian photoreceptor by directly interacting with core components of the circadian clock.
- Publication
Science (New York, N.Y.), 1999, Vol 285, Issue 5427, p553
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.285.5427.553