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- Title
Generation of a widespread Drosophila inversion by a transposable element.
- Authors
Cáceres, M; Ranz, J M; Barbadilla, A; Long, M; Ruiz, A
- Abstract
Although polymorphic inversions in Drosophila are very common, the origin of these chromosomal rearrangements is unclear. The breakpoints of the cosmopolitan inversion 2j of D. buzzatii were cloned and sequenced. Both breakpoints contain large insertions corresponding to a transposable element. It appears that the two pairs of target site duplications generated upon insertion were exchanged during the inversion event, and that the inversion arose by ectopic recombination between two copies of the transposon that were in opposite orientations. This is apparently the mechanism by which transposable elements generate natural inversions in Drosophila.
- Publication
Science (New York, N.Y.), 1999, Vol 285, Issue 5426, p415
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.285.5426.415