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- Title
BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator.
- Authors
Moore, P A; Belvedere, O; Orr, A; Pieri, K; LaFleur, D W; Feng, P; Soppet, D; Charters, M; Gentz, R; Parmelee, D; Li, Y; Galperina, O; Giri, J; Roschke, V; Nardelli, B; Carrell, J; Sosnovtseva, S; Greenfield, W; Ruben, S M; Olsen, H S; Fikes, J; Hilbert, D M
- Abstract
The tumor necrosis factor (TNF) superfamily of cytokines includes both soluble and membrane-bound proteins that regulate immune responses. A member of the human TNF family, BLyS (B lymphocyte stimulator), was identified that induced B cell proliferation and immunoglobulin secretion. BLyS expression on human monocytes could be up-regulated by interferon-gamma. Soluble BLyS functioned as a potent B cell growth factor in costimulation assays. Administration of soluble recombinant BLyS to mice disrupted splenic B and T cell zones and resulted in elevated serum immunoglobulin concentrations. The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation.
- Publication
Science (New York, N.Y.), 1999, Vol 285, Issue 5425, p260
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.285.5425.260