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- Title
The immunological synapse: a molecular machine controlling T cell activation.
- Authors
Grakoui, A; Bromley, S K; Sumen, C; Davis, M M; Shaw, A S; Allen, P M; Dustin, M L
- Abstract
The specialized junction between a T lymphocyte and an antigen-presenting cell, the immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring of adhesion molecules. Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands. Initially, T cell receptor ligands were engaged in an outermost ring of the nascent synapse. Transport of these complexes into the central cluster was dependent on T cell receptor-ligand interaction kinetics. Finally, formation of a stable central cluster at the heart of the synapse was a determinative event for T cell proliferation.
- Publication
Science (New York, N.Y.), 1999, Vol 285, Issue 5425, p221
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.285.5425.221