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- Title
A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.
- Authors
York, J D; Odom, A R; Murphy, R; Ives, E B; Wente, S R
- Abstract
In order to identify additional factors required for nuclear export of messenger RNA, a genetic screen was conducted with a yeast mutant deficient in a factor Gle1p, which associates with the nuclear pore complex (NPC). The three genes identified encode phospholipase C and two potential inositol polyphosphate kinases. Together, these constitute a signaling pathway from phosphatidylinositol 4, 5-bisphosphate to inositol hexakisphosphate (IP6). The common downstream effects of mutations in each component were deficiencies in IP6 synthesis and messenger RNA export, indicating a role for IP6 in GLE1 function and messenger RNA export.
- Publication
Science (New York, N.Y.), 1999, Vol 285, Issue 5424, p96
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.285.5424.96