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- Title
Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex.
- Authors
Westphal, R S; Tavalin, S J; Lin, J W; Alto, N M; Fraser, I D; Langeberg, L K; Sheng, M; Scott, J D
- Abstract
Regulation of N-methyl-D-aspartate (NMDA) receptor activity by kinases and phosphatases contributes to the modulation of synaptic transmission. Targeting of these enzymes near the substrate is proposed to enhance phosphorylation-dependent modulation. Yotiao, an NMDA receptor-associated protein, bound the type I protein phosphatase (PP1) and the adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase (PKA) holoenzyme. Anchored PP1 was active, limiting channel activity, whereas PKA activation overcame constitutive PP1 activity and conferred rapid enhancement of NMDA receptor currents. Hence, yotiao is a scaffold protein that physically attaches PP1 and PKA to NMDA receptors to regulate channel activity.
- Publication
Science (New York, N.Y.), 1999, Vol 285, Issue 5424, p93
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.285.5424.93