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- Title
Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption.
- Authors
Simon, D B; Lu, Y; Choate, K A; Velazquez, H; Al-Sabban, E; Praga, M; Casari, G; Bettinelli, A; Colussi, G; Rodriguez-Soriano, J; McCredie, D; Milford, D; Sanjad, S; Lifton, R P
- Abstract
Epithelia permit selective and regulated flux from apical to basolateral surfaces by transcellular passage through cells or paracellular flux between cells. Tight junctions constitute the barrier to paracellular conductance; however, little is known about the specific molecules that mediate paracellular permeabilities. Renal magnesium ion (Mg2+) resorption occurs predominantly through a paracellular conductance in the thick ascending limb of Henle (TAL). Here, positional cloning has identified a human gene, paracellin-1 (PCLN-1), mutations in which cause renal Mg2+ wasting. PCLN-1 is located in tight junctions of the TAL and is related to the claudin family of tight junction proteins. These findings provide insight into Mg2+ homeostasis, demonstrate the role of a tight junction protein in human disease, and identify an essential component of a selective paracellular conductance.
- Publication
Science (New York, N.Y.), 1999, Vol 285, Issue 5424, p103
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.285.5424.103