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- Title
Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila.
- Authors
Franc, N C; Heitzler, P; Ezekowitz, R A; White, K
- Abstract
Macrophages in the Drosophila embryo are responsible for the phagocytosis of apoptotic cells and are competent to engulf bacteria. Croquemort (CRQ) is a CD36-related receptor expressed exclusively on these macrophages. Genetic evidence showed that crq was essential for efficient phagocytosis of apoptotic corpses but was not required for the engulfment of bacteria. The expression of CRQ was regulated by the amount of apoptosis. These data define distinct pathways for the phagocytosis of corpses and bacteria in Drosophila.
- Publication
Science (New York, N.Y.), 1999, Vol 284, Issue 5422, p1991
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.284.5422.1991