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- Title
Preventing neurodegeneration in the Drosophila mutant bubblegum.
- Authors
Min, K T; Benzer, S
- Abstract
The Drosophila melanogaster recessive mutant bubblegum (bgm) exhibits adult neurodegeneration, with marked dilation of photoreceptor axons. The bubblegum mutant shows elevated levels of very long chain fatty acids (VLCFAs), as seen in the human disease adrenoleukodystrophy (ALD). In ALD, the excess can be lowered by dietary treatment with "Lorenzo's oil," a mixture of unsaturated fatty acids. Feeding the fly mutant one of the components, glyceryl trioleate oil, blocked the accumulation of excess VLCFAs as well as development of the pathology. Mutant flies thus provide a potential model system for studying mechanisms of neurodegenerative disease and screening drugs for treatment.
- Publication
Science (New York, N.Y.), 1999, Vol 284, Issue 5422, p1985
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.284.5422.1985