We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.
- Authors
Tortorella, M D; Burn, T C; Pratta, M A; Abbaszade, I; Hollis, J M; Liu, R; Rosenfeld, S A; Copeland, R A; Decicco, C P; Wynn, R; Rockwell, A; Yang, F; Duke, J L; Solomon, K; George, H; Bruckner, R; Nagase, H; Itoh, Y; Ellis, D M; Ross, H; Wiswall, B H; Murphy, K; Hillman, M C, Jr; Hollis, G F; Newton, R C; Magolda, R L; Trzaskos, J M; Arner, E C
- Abstract
We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage aggrecan in arthritic diseases. Aggrecanase-1 [a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4)] is a member of the ADAMTS protein family that cleaves aggrecan at the glutamic acid-373-alanine-374 bond. The identification of this protease provides a specific target for the development of therapeutics to prevent cartilage degradation in arthritis.
- Publication
Science (New York, N.Y.), 1999, Vol 284, Issue 5420, p1664
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.284.5420.1664