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- Title
Genetic control of branching morphogenesis.
- Authors
Metzger, R J; Krasnow, M A
- Abstract
The genetic programs that direct formation of the treelike branching structures of two animal organs have begun to be elucidated. In both the developing Drosophila tracheal (respiratory) system and mammalian lung, a fibroblast growth factor (FGF) signaling pathway is reiteratively used to pattern successive rounds of branching. The initial pattern of signaling appears to be established by early, more global embryonic patterning systems. The FGF pathway is then modified at each stage of branching by genetic feedback controls and other signals to give distinct branching outcomes. The reiterative use of a signaling pathway by both insects and mammals suggests a general scheme for patterning branching morphogenesis.
- Publication
Science (New York, N.Y.), 1999, Vol 284, Issue 5420, p1635
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.284.5420.1635