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- Title
Helicobacter pylori virulence and genetic geography.
- Authors
Covacci, A; Telford, J L; Del Giudice, G; Parsonnet, J; Rappuoli, R
- Abstract
Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is responsible for gastritis, peptic ulcer, and gastric cancer. A pathogenicity island acquired by horizontal transfer, coding for a type IV secretion system, is a major determinant of virulence. The infection is now treated with antibiotics, and vaccines are in preparation. The geographic distribution suggests coevolution of man and Helicobacter pylori.
- Publication
Science (New York, N.Y.), 1999, Vol 284, Issue 5418, p1328
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.284.5418.1328