We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Phylogenetic perspectives in innate immunity.
- Authors
Hoffmann, J A; Kafatos, F C; Janeway, C A; Ezekowitz, R A
- Abstract
The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.
- Publication
Science (New York, N.Y.), 1999, Vol 284, Issue 5418, p1313
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.284.5418.1313