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- Title
Mechanism of intrinsic transcription termination and antitermination.
- Authors
Yarnell, W S; Roberts, J W
- Abstract
Gene expression is modulated by regulatory elements that influence transcription elongation by RNA polymerase: terminators that disrupt the elongation complex and release RNA, and regulators that overcome termination signals. RNA release from Escherichia coli RNA polymerase can be induced by a complementary oligonucleotide that replaces the upstream half of the RNA hairpin stem of intrinsic terminator transcripts, implying that RNA hairpins act by extracting RNA from the transcription complex. A transcription antiterminator inhibits this activity of oligonucleotides and therefore protects the elongation complex from destabilizing attacks on the emerging transcript. These effects illuminate the structure of the complex and the mechanism of transcription termination.
- Publication
Science (New York, N.Y.), 1999, Vol 284, Issue 5414, p611
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.284.5414.611