We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors.
- Authors
Freedman, M S; Lucas, R J; Soni, B; von Schantz, M; Muñoz, M; David-Gray, Z; Foster, R
- Abstract
Circadian rhythms of mammals are entrained by light to follow the daily solar cycle (photoentrainment). To determine whether retinal rods and cones are required for this response, the effects of light on the regulation of circadian wheel-running behavior were examined in mice lacking these photoreceptors. Mice without cones (cl) or without both rods and cones (rdta/cl) showed unattenuated phase-shifting responses to light. Removal of the eyes abolishes this behavior. Thus, neither rods nor cones are required for photoentrainment, and the murine eye contains additional photoreceptors that regulate the circadian clock.
- Publication
Science (New York, N.Y.), 1999, Vol 284, Issue 5413, p502
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.284.5413.502