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- Title
Control of mRNA decay by heat shock-ubiquitin-proteasome pathway.
- Authors
Laroia, G; Cuesta, R; Brewer, G; Schneider, R J
- Abstract
Cytokine and proto-oncogene messenger RNAs (mRNAs) are rapidly degraded through AU-rich elements in the 3' untranslated region. Rapid decay involves AU-rich binding protein AUF1, which complexes with heat shock proteins hsc70-hsp70, translation initiation factor eIF4G, and poly(A) binding protein. AU-rich mRNA decay is associated with displacement of eIF4G from AUF1, ubiquitination of AUF1, and degradation of AUF1 by proteasomes. Induction of hsp70 by heat shock, down-regulation of the ubiquitin-proteasome network, or inactivation of ubiquitinating enzyme E1 all result in hsp70 sequestration of AUF1 in the perinucleus-nucleus, and all three processes block decay of AU-rich mRNAs and AUF1 protein. These results link the rapid degradation of cytokine mRNAs to the ubiquitin-proteasome pathway.
- Publication
Science (New York, N.Y.), 1999, Vol 284, Issue 5413, p499
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.284.5413.499