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- Title
Multilineage potential of adult human mesenchymal stem cells.
- Authors
Pittenger, M F; Mackay, A M; Beck, S C; Jaiswal, R K; Douglas, R; Mosca, J D; Moorman, M A; Simonetti, D W; Craig, S; Marshak, D R
- Abstract
Human mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage, fat, tendon, muscle, and marrow stroma. Cells that have the characteristics of human mesenchymal stem cells were isolated from marrow aspirates of volunteer donors. These cells displayed a stable phenotype and remained as a monolayer in vitro. These adult stem cells could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages. Individual stem cells were identified that, when expanded to colonies, retained their multilineage potential.
- Publication
Science (New York, N.Y.), 1999, Vol 284, Issue 5411, p143
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.284.5411.143