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- Title
Inhibition of myosin light chain kinase by p21-activated kinase.
- Authors
Sanders, L C; Matsumura, F; Bokoch, G M; de Lanerolle, P
- Abstract
p21-activated kinases (PAKs) are implicated in the cytoskeletal changes induced by the Rho family of guanosine triphosphatases. Cytoskeletal dynamics are primarily modulated by interactions of actin and myosin II that are regulated by myosin light chain kinase (MLCK)-mediated phosphorylation of the regulatory myosin light chain (MLC). p21-activated kinase 1 (PAK1) phosphorylates MLCK, resulting in decreased MLCK activity. MLCK activity and MLC phosphorylation were decreased, and cell spreading was inhibited in baby hamster kidney-21 and HeLa cells expressing constitutively active PAK1. These data indicate that MLCK is a target for PAKs and that PAKs may regulate cytoskeletal dynamics by decreasing MLCK activity and MLC phosphorylation.
- Publication
Science (New York, N.Y.), 1999, Vol 283, Issue 5410, p2083
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.283.5410.2083