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- Title
Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules.
- Authors
Sánchez, L M; Chirino, A J; Bjorkman, P j
- Abstract
Zn-alpha2-glycoprotein (ZAG) is a soluble protein that is present in serum and other body fluids. ZAG stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. The 2.8 angstrom crystal structure of ZAG resembles a class I major histocompatibility complex (MHC) heavy chain, but ZAG does not bind the class I light chain beta2-microglobulin. The ZAG structure includes a large groove analogous to class I MHC peptide binding grooves. Instead of a peptide, the ZAG groove contains a nonpeptidic compound that may be implicated in lipid catabolism under normal or pathological conditions.
- Publication
Science (New York, N.Y.), 1999, Vol 283, Issue 5409, p1914
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.283.5409.1914