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- Title
Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1.
- Authors
Staab, J F; Bradway, S D; Fidel, P L; Sundstrom, P
- Abstract
The pathogenesis of candidiasis involves invasion of host tissues by filamentous forms of the opportunistic yeast Candida albicans. Morphology-specific gene products may confer proinvasive properties. A hypha-specific surface protein, Hwp1, with similarities to mammalian small proline-rich proteins was shown to serve as a substrate for mammalian transglutaminases. Candida albicans strains lacking Hwp1 were unable to form stable attachments to human buccal epithelial cells and had a reduced capacity to cause systemic candidiasis in mice. This represents a paradigm for microbial adhesion that implicates essential host enzymes.
- Publication
Science (New York, N.Y.), 1999, Vol 283, Issue 5407, p1535
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.283.5407.1535