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- Title
Exon shuffling by L1 retrotransposition.
- Authors
Moran, J V; DeBerardinis, R J; Kazazian, H H, Jr
- Abstract
Long interspersed nuclear elements (LINE-1s or L1s) are the most abundant retrotransposons in the human genome, and they serve as major sources of reverse transcriptase activity. Engineered L1s retrotranspose at high frequency in cultured human cells. Here it is shown that L1s insert into transcribed genes and retrotranspose sequences derived from their 3' flanks to new genomic locations. Thus, retrotransposition-competent L1s provide a vehicle to mobilize non-L1 sequences, such as exons or promoters, into existing genes and may represent a general mechanism for the evolution of new genes.
- Publication
Science (New York, N.Y.), 1999, Vol 283, Issue 5407, p1530
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.283.5407.1530