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- Title
Oxidative phosphorylation at the fin de siècle.
- Authors
Saraste, M
- Abstract
Mitochondria produce most of the energy in animal cells by a process called oxidative phosphorylation. Electrons are passed along a series of respiratory enzyme complexes located in the inner mitochondrial membrane, and the energy released by this electron transfer is used to pump protons across the membrane. The resultant electrochemical gradient enables another complex, adenosine 5'-triphosphate (ATP) synthase, to synthesize the energy carrier ATP. Important new mechanistic insights into oxidative phosphorylation have emerged from recent three-dimensional structural analyses of ATP synthase and two of the respiratory enzyme complexes, cytochrome bc1 and cytochrome c oxidase. This work, and new enzymological studies of ATP synthase's unusual catalytic mechanism, are reviewed here.
- Publication
Science (New York, N.Y.), 1999, Vol 283, Issue 5407, p1488
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.283.5407.1488