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- Title
Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes.
- Authors
Schmitz, J E; Kuroda, M J; Santra, S; Sasseville, V G; Simon, M A; Lifton, M A; Racz, P; Tenner-Racz, K; Dalesandro, M; Scallon, B J; Ghrayeb, J; Forman, M A; Montefiori, D C; Rieber, E P; Letvin, N L; Reimann, K A
- Abstract
Clinical evidence suggests that cellular immunity is involved in controlling human immunodeficiency virus-1 (HIV-1) replication. An animal model of acquired immune deficiency syndrome (AIDS), the simian immunodeficiency virus (SIV)-infected rhesus monkey, was used to show that virus replication is not controlled in monkeys depleted of CD8+ lymphocytes during primary SIV infection. Eliminating CD8+ lymphocytes from monkeys during chronic SIV infection resulted in a rapid and marked increase in viremia that was again suppressed coincident with the reappearance of SIV-specific CD8+ T cells. These results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses.
- Publication
Science (New York, N.Y.), 1999, Vol 283, Issue 5403, p857
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.283.5403.857