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- Title
Oligomeric structure of the human EphB2 receptor SAM domain.
- Authors
Thanos, C D; Goodwill, K E; Bowie, J U
- Abstract
The sterile alpha motif (SAM) domain is a protein interaction module that is present in diverse signal-transducing proteins. SAM domains are known to form homo- and hetero-oligomers. The crystal structure of the SAM domain from an Eph receptor tyrosine kinase, EphB2, reveals two large interfaces. In one interface, adjacent monomers exchange amino-terminal peptides that insert into a hydrophobic groove on each neighbor. A second interface is composed of the carboxyl-terminal helix and a nearby loop. A possible oligomer, constructed from a combination of these binding modes, may provide a platform for the formation of larger protein complexes.
- Publication
Science (New York, N.Y.), 1999, Vol 283, Issue 5403, p833
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.283.5403.833