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- Title
Diminishing returns from mutation supply rate in asexual populations.
- Authors
Arjan, J A; Visser, M; Zeyl, C W; Gerrish, P J; Blanchard, J L; Lenski, R E
- Abstract
Mutator genotypes with increased mutation rates may be especially important in microbial evolution if genetic adaptation is generally limited by the supply of mutations. In experimental populations of the bacterium Escherichia coli, the rate of evolutionary adaptation was proportional to the mutation supply rate only in particular circumstances of small or initially well-adapted populations. These experiments also demonstrate a "speed limit" on adaptive evolution in asexual populations, one that is independent of the mutation supply rate.
- Publication
Science (New York, N.Y.), 1999, Vol 283, Issue 5400, p404
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.283.5400.404