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- Title
A molecular mechanism for electrical tuning of cochlear hair cells.
- Authors
Ramanathan, K; Michael, T H; Jiang, G J; Hiel, H; Fuchs, P A
- Abstract
Cochlear frequency selectivity in lower vertebrates arises in part from electrical tuning intrinsic to the sensory hair cells. The resonant frequency is determined largely by the gating kinetics of calcium-activated potassium (BK) channels encoded by the slo gene. Alternative splicing of slo from chick cochlea generated kinetically distinct BK channels. Combination with accessory beta subunits slowed the gating kinetics of alpha splice variants but preserved relative differences between them. In situ hybridization showed that the beta subunit is preferentially expressed by low-frequency (apical) hair cells in the avian cochlea. Interaction of beta with alpha splice variants could provide the kinetic range needed for electrical tuning of cochlear hair cells.
- Publication
Science (New York, N.Y.), 1999, Vol 283, Issue 5399, p215
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.283.5399.215