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- Title
The transcriptional program in the response of human fibroblasts to serum.
- Authors
Iyer, V R; Eisen, M B; Ross, D T; Schuler, G; Moore, T; Lee, J C; Trent, J M; Staudt, L M; Hudson, J, Jr; Boguski, M S; Lashkari, D; Shalon, D; Botstein, D; Brown, P O
- Abstract
The temporal program of gene expression during a model physiological response of human cells, the response of fibroblasts to serum, was explored with a complementary DNA microarray representing about 8600 different human genes. Genes could be clustered into groups on the basis of their temporal patterns of expression in this program. Many features of the transcriptional program appeared to be related to the physiology of wound repair, suggesting that fibroblasts play a larger and richer role in this complex multicellular response than had previously been appreciated.
- Publication
Science (New York, N.Y.), 1999, Vol 283, Issue 5398, p83
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.283.5398.83